General Information

  • ID:  hor005537
  • Uniprot ID:  Q23756
  • Protein name:  Pigment-dispersing hormone 2
  • Gene name:  PDH2
  • Organism:  Callinectes sapidus (Blue crab)
  • Family:  Arthropod PDH family
  • Source:  animal
  • Expression:  Eyestalk sinus gland.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Callinectes (genus), Portuninae (subfamily), Portunidae (family), Portunoidea (superfamily), Heterotremata, Eubrachyura, Brachyura (infraorder), Pleocyemata (suborder), Decapoda (order), Eucarida (superorder), Eumalacostraca (subclass), Malacostraca (class), Multicrustacea (superclass), Crustacea (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction; GO:0007268 chemical synaptic transmission
  • GO CC:  GO:0005576 extracellular region; GO:0045202 synapse

Sequence Information

  • Sequence:  NSELINSLLGISALMNEA
  • Length:  18(58-75)
  • Propeptide:  MRSGVFVAVLVVVVFALLTQGQELHVPEREAVANLAARILKIVHAPHDAAAGVPHKRNSELINSLLGISALMNEAGRR
  • Signal peptide:  MRSGVFVAVLVVVVFALLTQG
  • Modification:  T18 Alanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Causes the migration of the distal retinal pigment into the proximal end of the pigment chromatophore cells and thus decreases the amount of light entering the retinulas. May also function as a neurotransmitter and/or neuromodulator
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q23756-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor005537_AF2.pdbhor005537_ESM.pdb

Physical Information

Mass: 219257 Formula: C80H137N21O29S
Absent amino acids: CDFHKPQRTVWY Common amino acids: L
pI: 3.61 Basic residues: 0
Polar residues: 7 Hydrophobic residues: 8
Hydrophobicity: 52.22 Boman Index: -731
Half-Life: 1.4 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 141.11
Instability Index: 1442.78 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  7999056
  • Title:  Molecular cloning of two pigment-dispersing hormone (PDH) precursors in the blue crab Callinectes sapidus reveals a novel member of the PDH neuropeptide family.